Chromium Polynicotinate is a nutritional supplement designed primarily as nutritional support for certain conditions that are typical for sufferers from diabetes mellitus type 2 or age related diabetes. Recent studies have revealed that supplemented chromium can reduce high blood glucose levels, lowering or eliminating nonenzymatic glycation. Further studies reveal that supplementing chromium polynicotinate can help with depression symptoms as well as reduce systolic blood pressure elevation caused by sucrose. People with chromium deficiencies have trouble maintaining stable blood sugar levels. Chromium polynicotinate can assist in regulating the levels of blood sugar, but it also helps with the control of cholesterol, promote the fat removal process and encourage buildup of lean muscles. For these characteristics it is a popular supplement for body building and any muscle building sports enthusiasts.

Garcinia Cambogia is a natural extract that comes from a fruit located in India and is prominent in a plethora of different natural weight loss products.

Guarana is a South American climbing plant belonging to the genus of trees and shrubs called Maple. This plant is common around the Amazon and very present in Brazil. The fruit of the guarana plant is being used in that country to produce a diversity of soft drinks and beverages, having the double caffeine content of the coffee bean. Other nutrients that are contained in the seed besides caffeine are protein, fat and starch, but also adenine, choline, guanine, resin, tannin and xanthine, just to name a few. The cognitive effects of guarana are well documented, but the appetite suppressant qualities of guarana are relatively new. A study has proven that a combination of yerba mate, guarana and damiana leads to a tenfold weight loss quantity when compared with a placebo.

Hoodia Gordonii grows in Namibia and South Africa naturally. It is a leafless spiny plant useful for medicinal purposes. These flowers are pollinated by flies mainly as they smell identical to rotten meat. Hoodia is known long by indigenous population and is infrequently used for treating small infections and indigestion. This is used to suppress appetite during long hunting trips such as Kalahari Desert that interests more tourists. Hoodia Gordonii was prominent for it appetite suppressing effect and hence was collaborated with Pfizer, a pharmaceutical company to deal with obesity. However, it was stopped as it is stated to have indications of effects on liver. Hoodia Gordonii is wild harvested by individuals as well as by few companies that are granted license. However, there is no evidence of Hoodia working in humans as appetite suppressant. Due to the lack of clarity and fear of breaking down of liver, it is not recommended for obesity.

Synthetic Guggulsterones, which is a form of orally administered guggulipid, which increases T3 (tryiidothyronine) levels in animal models. T3 is the conversion product of T4, which is produced by the thyroid gland. Thyroid hormone levels are closely involved in metabolic function. Increased thyroid levels can cause more fat to be burned and stored. While on a diet, the body responds by decreasing T3 levels, therefor decreasing metabolic rate. It is not known how guggulipid increases T3 levels. Guggul, also called guggulipid, is an ethyl acetate extract of the gum resin of the guggul tree.