Bioperine, a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. Bioperine is used in conjunction with other herbs or vitamins to increase their absorption and digestion to make them more effective.

Caffeine is the most widely used legal stimulant of the central nervous system and is also used in ThermoLean, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Guggulsterone- Commiphora wightii, or the so called Guggul tree is a flowering shrub or rather a small tree which can grow up to a size of 4 meters. Once very common in India, it is now there listed as endangered, but not in northern Africa or elsewhere in central Asia. It was very popular in the Indian Ayurvedic medicine, but also currently in the western medicine for treating of heart problems. The hydrocarbon secretion of Guggul contains a plant sterol, guggulsterone, which in the human body seems to act as an antagonist to the farnesoid X receptor. Furthermore, guggulsterone is active in increasing the natural thyroid production. This in turn stimulates the metabolism and may raise the body temperature, burning stored excess fat.

Synephrine is an ingredient that is obtained mainly from the fruit of a small citrus tree, the Citrus aurantium, also known as bitter orange, zhi shi and sour orange. Synephrine is viewed as the safer version of ephedrine, whereby the properties include weight loss, increased fat burning, raised metabolism, as well as boosted energy levels. With such properties, this drug became instantly popular with the weight loss and control circles, but also with the body building community, and is now used in ThermoLean where fat burning and higher energy level properties are eagerly sought after. Initial research show stimulation of beta-3 receptors, whereby no increased heart rate or blood pressure was observed. It seems that synephrine induces lipolysis and stimulates similarly to caffeine. Some have also observed that synephrine suppresses appetite and increases the metabolic rate.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.